Drug interactions
Diethylpropion + Procarbazine
Severity: Contraindicated
Diethylpropion and Procarbazine: contraindicated interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diethylpropion is an amphetamine-like anorectic with sympathomimetic activity, and procarbazine inhibits MAO. Together they can precipitate a hypertensive crisis.
What this interaction means in plain words
Diethylpropion and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition potentiates indirect-acting sympathomimetic release of noradrenaline.
What to do
Avoid the combination, and leave at least 14 days after stopping procarbazine before using diethylpropion.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Diethylpropion with Procarbazine?
MediHelp rates the interaction as contraindicated. Diethylpropion and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Diethylpropion is an amphetamine-like anorectic with sympathomimetic activity, and procarbazine inhibits MAO. Together they can precipitate a hypertensive crisis.
How serious is the interaction between Diethylpropion and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, and leave at least 14 days after stopping procarbazine before using diethylpropion.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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