Drug interactions
Diethylpropion + Tranylcypromine
Severity: Contraindicated
Diethylpropion and Tranylcypromine: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diethylpropion is a sympathomimetic appetite suppressant that promotes catecholamine release. With an MAOI it may precipitate hypertensive crisis.
What this interaction means in plain words
Diethylpropion and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Sympathomimetic catecholamine release combined with MAO inhibition produces exaggerated pressor effects.
What to do
Avoid during and for 14 days after MAOI therapy. Use a non-sympathomimetic approach to weight management.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Diethylpropion with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Diethylpropion and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Diethylpropion is a sympathomimetic appetite suppressant that promotes catecholamine release. With an MAOI it may precipitate hypertensive crisis.
How serious is the interaction between Diethylpropion and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during and for 14 days after MAOI therapy. Use a non-sympathomimetic approach to weight management.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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