Drug interactions
Difenoxin + Maprotiline
Severity: Moderate
Difenoxin and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difenoxin is an opioid-related antidiarrheal and can cause drowsiness, while maprotiline is sedating, so the combination may increase CNS depression. Anticholinergic effects on gut motility may also add up and raise the risk of constipation or ileus.
What this interaction means in plain words
Difenoxin and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Difenoxin belongs to Gastrointestinal Tract; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Use the lowest effective difenoxin dose and monitor for sedation and abdominal distension. Advise against driving until the effect is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Difenoxin
Frequently asked questions
Can I take Difenoxin with Maprotiline?
MediHelp rates the interaction as moderate. Difenoxin and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difenoxin is an opioid-related antidiarrheal and can cause drowsiness, while maprotiline is sedating, so the combination may increase CNS depression. Anticholinergic effects on gut motility may also add up and raise the risk of constipation or ileus.
How serious is the interaction between Difenoxin and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective difenoxin dose and monitor for sedation and abdominal distension. Advise against driving until the effect is known.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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