Drug interactions
Difenoxin + Tranylcypromine
Severity: Major
Difenoxin and Tranylcypromine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difenoxin is the active metabolite of diphenoxylate, and its labeling warns that MAO inhibitors may precipitate hypertensive crisis. CNS depression and anticholinergic effects may also be increased.
What this interaction means in plain words
Difenoxin and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Difenoxin belongs to Gastrointestinal Tract; Tranylcypromine belongs to Central Nervous System.
Why it happens
MAO inhibition may potentiate the pressor and CNS effects of this opioid-related antidiarrheal; the precise mechanism is not established.
What to do
Avoid use with tranylcypromine and for 14 days after stopping it; use a different antidiarrheal such as loperamide if appropriate. If it is given, monitor blood pressure and sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Difenoxin
Frequently asked questions
Can I take Difenoxin with Tranylcypromine?
MediHelp rates the interaction as major. Difenoxin and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Difenoxin is the active metabolite of diphenoxylate, and its labeling warns that MAO inhibitors may precipitate hypertensive crisis. CNS depression and anticholinergic effects may also be increased.
How serious is the interaction between Difenoxin and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid use with tranylcypromine and for 14 days after stopping it; use a different antidiarrheal such as loperamide if appropriate. If it is given, monitor blood pressure and sedation.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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