Drug interactions
Diflunisal + Dong quai
Severity: Moderate
Diflunisal and Dong quai: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dong quai contains coumarin-type constituents and may have antiplatelet properties, potentially adding to the bleeding risk of NSAIDs. Documented clinical cases are limited.
What this interaction means in plain words
Diflunisal and Dong quai can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive effects on coagulation and platelet function from coumarin constituents combined with NSAID platelet inhibition.
What to do
Advise avoiding dong quai while taking diflunisal, or monitor for bruising and bleeding if use continues.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Diflunisal with Dong quai?
MediHelp rates the interaction as moderate. Diflunisal and Dong quai can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dong quai contains coumarin-type constituents and may have antiplatelet properties, potentially adding to the bleeding risk of NSAIDs. Documented clinical cases are limited.
How serious is the interaction between Diflunisal and Dong quai?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding dong quai while taking diflunisal, or monitor for bruising and bleeding if use continues.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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