Drug interactions
Diflunisal + Doxazosin
Severity: Moderate
Diflunisal and Doxazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diflunisal, like other NSAIDs, may reduce the antihypertensive effect of doxazosin through renal sodium and water retention. Clinically relevant loss of blood pressure control is possible with sustained use.
What this interaction means in plain words
Diflunisal and Doxazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Doxazosin belongs to Genitourinary.
Why it happens
Prostaglandin synthesis inhibition causes sodium retention and vasoconstriction.
What to do
Monitor blood pressure during concurrent use and adjust doxazosin if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Diflunisal with Doxazosin?
MediHelp rates the interaction as moderate. Diflunisal and Doxazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diflunisal, like other NSAIDs, may reduce the antihypertensive effect of doxazosin through renal sodium and water retention. Clinically relevant loss of blood pressure control is possible with sustained use.
How serious is the interaction between Diflunisal and Doxazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during concurrent use and adjust doxazosin if control worsens.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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