Drug interactions
Diflunisal + Fenbufen
Severity: Major
Diflunisal and Fenbufen: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking two NSAIDs together increases gastrointestinal bleeding, renal injury and hyperkalemia risk without improving pain relief. This duplication should be avoided.
What this interaction means in plain words
Diflunisal and Fenbufen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive cyclooxygenase inhibition causing greater loss of gastroprotective and renal prostaglandins and platelet inhibition.
What to do
Avoid combining two NSAIDs and use a single agent at the lowest effective dose. Monitor for bleeding and renal function if overlap occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Diflunisal with Fenbufen?
MediHelp rates the interaction as major. Diflunisal and Fenbufen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Taking two NSAIDs together increases gastrointestinal bleeding, renal injury and hyperkalemia risk without improving pain relief. This duplication should be avoided.
How serious is the interaction between Diflunisal and Fenbufen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two NSAIDs and use a single agent at the lowest effective dose. Monitor for bleeding and renal function if overlap occurs.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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