Drug interactions
Diflunisal + Fish oil triglycerides
Severity: Minor
Diflunisal and Fish oil triglycerides: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omega-3 fatty acids can modestly prolong bleeding time, and combining them with an NSAID may slightly increase bleeding tendency. Clinically significant bleeding is uncommon.
What this interaction means in plain words
Diflunisal and Fish oil triglycerides have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive effect on platelet function: omega-3 fatty acids reduce platelet aggregability while diflunisal inhibits cyclooxygenase.
What to do
No routine change is needed; monitor for bleeding in patients with other risk factors such as anticoagulant use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Diflunisal with Fish oil triglycerides?
MediHelp rates the interaction as minor. Diflunisal and Fish oil triglycerides have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omega-3 fatty acids can modestly prolong bleeding time, and combining them with an NSAID may slightly increase bleeding tendency. Clinically significant bleeding is uncommon.
How serious is the interaction between Diflunisal and Fish oil triglycerides?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor for bleeding in patients with other risk factors such as anticoagulant use.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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