Drug interactions
Diflunisal + Ganciclovir
Severity: Minor
Diflunisal and Ganciclovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganciclovir is cleared renally by filtration and tubular secretion, and NSAIDs may reduce renal function and compete for secretion. This may raise ganciclovir exposure and increase hematologic and renal toxicity, mainly in patients with renal impairment.
What this interaction means in plain words
Diflunisal and Ganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diflunisal belongs to Musculoskeletal; Ganciclovir belongs to Anti Virals.
Why it happens
Possible competition for renal tubular secretion and NSAID-related reduction in renal perfusion.
What to do
Monitor renal function and blood counts when the combination is needed, and adjust ganciclovir dose to creatinine clearance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Ganciclovir
Frequently asked questions
Can I take Diflunisal with Ganciclovir?
MediHelp rates the interaction as minor. Diflunisal and Ganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ganciclovir is cleared renally by filtration and tubular secretion, and NSAIDs may reduce renal function and compete for secretion. This may raise ganciclovir exposure and increase hematologic and renal toxicity, mainly in patients with renal impairment.
How serious is the interaction between Diflunisal and Ganciclovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and blood counts when the combination is needed, and adjust ganciclovir dose to creatinine clearance.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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