Drug interactions
Diflunisal + Ginkgo biloba
Severity: Moderate
Diflunisal and Ginkgo biloba: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ginkgo inhibits platelet-activating factor and has been linked to case reports of bleeding, so combining it with an NSAID may increase bleeding risk. Controlled studies have been inconsistent.
What this interaction means in plain words
Diflunisal and Ginkgo biloba can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects: ginkgolides antagonize platelet-activating factor while diflunisal inhibits cyclooxygenase.
What to do
Advise avoiding ginkgo supplements during diflunisal therapy, and monitor for bleeding if used together.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Diflunisal with Ginkgo biloba?
MediHelp rates the interaction as moderate. Diflunisal and Ginkgo biloba can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ginkgo inhibits platelet-activating factor and has been linked to case reports of bleeding, so combining it with an NSAID may increase bleeding risk. Controlled studies have been inconsistent.
How serious is the interaction between Diflunisal and Ginkgo biloba?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding ginkgo supplements during diflunisal therapy, and monitor for bleeding if used together.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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