Drug interactions
Diflunisal + Glimepiride-pioglitazone
Severity: Moderate
Diflunisal and Glimepiride-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diflunisal, a highly protein-bound salicylate NSAID, may enhance the hypoglycemic effect of glimepiride. Episodes of low blood glucose may occur, particularly in older or renally impaired patients.
What this interaction means in plain words
Diflunisal and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Possible competition for plasma protein binding and salicylate-related effects on glucose; mechanism not firmly established.
What to do
Monitor blood glucose when the NSAID is started or stopped and lower the glimepiride dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Diflunisal with Glimepiride-pioglitazone?
MediHelp rates the interaction as moderate. Diflunisal and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diflunisal, a highly protein-bound salicylate NSAID, may enhance the hypoglycemic effect of glimepiride. Episodes of low blood glucose may occur, particularly in older or renally impaired patients.
How serious is the interaction between Diflunisal and Glimepiride-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when the NSAID is started or stopped and lower the glimepiride dose if hypoglycemia develops.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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