Drug interactions
Diflunisal + Horse chestnut seed
Severity: Minor
Diflunisal and Horse chestnut seed: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Horse chestnut contains aescin and, in some preparations, coumarin-like compounds that may theoretically increase bleeding risk with NSAIDs. Clinical data are scarce.
What this interaction means in plain words
Diflunisal and Horse chestnut seed have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive effect on hemostasis from coumarin-type constituents and platelet effects.
What to do
Advise patients to report bleeding or bruising; avoid combining if other anticoagulant or antiplatelet drugs are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Diflunisal with Horse chestnut seed?
MediHelp rates the interaction as minor. Diflunisal and Horse chestnut seed have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Horse chestnut contains aescin and, in some preparations, coumarin-like compounds that may theoretically increase bleeding risk with NSAIDs. Clinical data are scarce.
How serious is the interaction between Diflunisal and Horse chestnut seed?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to report bleeding or bruising; avoid combining if other anticoagulant or antiplatelet drugs are used.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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