Drug interactions
Diflunisal + Indapamide
Severity: Moderate
Diflunisal and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the antihypertensive and diuretic effect of indapamide and, in volume-depleted patients, raise the risk of renal impairment.
What this interaction means in plain words
Diflunisal and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Indapamide belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and water retention and reduced renal perfusion.
What to do
Monitor blood pressure, renal function and electrolytes, and ensure adequate hydration. Adjust antihypertensive therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Indapamide
Frequently asked questions
Can I take Diflunisal with Indapamide?
MediHelp rates the interaction as moderate. Diflunisal and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the antihypertensive and diuretic effect of indapamide and, in volume-depleted patients, raise the risk of renal impairment.
How serious is the interaction between Diflunisal and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes, and ensure adequate hydration. Adjust antihypertensive therapy if needed.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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