Drug interactions
Diflunisal + Insulin lispro
Severity: Minor
Diflunisal and Insulin lispro: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates such as diflunisal may lower blood glucose, particularly at high doses, and can add to the effect of insulin. This may occasionally lead to hypoglycemia in patients on tight glycemic control.
What this interaction means in plain words
Diflunisal and Insulin lispro have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diflunisal belongs to Musculoskeletal; Insulin lispro belongs to Endocrine.
Why it happens
High-dose salicylates can enhance insulin secretion and sensitivity and reduce hepatic glucose output, adding to the glucose lowering of insulin.
What to do
Monitor blood glucose when starting or stopping regular high-dose diflunisal and adjust the insulin dose if glucose falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Insulin lispro
Frequently asked questions
Can I take Diflunisal with Insulin lispro?
MediHelp rates the interaction as minor. Diflunisal and Insulin lispro have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salicylates such as diflunisal may lower blood glucose, particularly at high doses, and can add to the effect of insulin. This may occasionally lead to hypoglycemia in patients on tight glycemic control.
How serious is the interaction between Diflunisal and Insulin lispro?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping regular high-dose diflunisal and adjust the insulin dose if glucose falls.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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