Drug interactions
Diflunisal + Latanoprostene bunod
Severity: Minor
Diflunisal and Latanoprostene bunod: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic NSAIDs may alter the intraocular pressure response to ophthalmic prostaglandin analogues, with conflicting reports of reduced or increased effect. The clinical effect is unpredictable and usually small.
What this interaction means in plain words
Diflunisal and Latanoprostene bunod have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Not firmly established; NSAIDs inhibit prostaglandin synthesis and may interfere with the uveoscleral outflow effects of prostaglandin analogues.
What to do
Monitor intraocular pressure when an NSAID is started or stopped in a patient treated with latanoprostene bunod.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Diflunisal with Latanoprostene bunod?
MediHelp rates the interaction as minor. Diflunisal and Latanoprostene bunod have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic NSAIDs may alter the intraocular pressure response to ophthalmic prostaglandin analogues, with conflicting reports of reduced or increased effect. The clinical effect is unpredictable and usually small.
How serious is the interaction between Diflunisal and Latanoprostene bunod?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor intraocular pressure when an NSAID is started or stopped in a patient treated with latanoprostene bunod.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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