Drug interactions
Diflunisal + Meclofenamate
Severity: Major
Diflunisal and Meclofenamate: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two systemic NSAIDs together provide no added benefit and increase gastrointestinal, renal and bleeding toxicity. Hyperkalemia and fluid retention are also more likely.
What this interaction means in plain words
Diflunisal and Meclofenamate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive inhibition of cyclooxygenase leads to cumulative effects on gastric mucosa, platelet function and renal prostaglandin-dependent perfusion.
What to do
Avoid concurrent use of two NSAIDs and use a single agent at the lowest effective dose. If a switch is needed, stop one before starting the other.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Diflunisal with Meclofenamate?
MediHelp rates the interaction as major. Diflunisal and Meclofenamate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Two systemic NSAIDs together provide no added benefit and increase gastrointestinal, renal and bleeding toxicity. Hyperkalemia and fluid retention are also more likely.
How serious is the interaction between Diflunisal and Meclofenamate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two NSAIDs and use a single agent at the lowest effective dose. If a switch is needed, stop one before starting the other.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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