Drug interactions
Diflunisal + Methyl aminolevulinate
Severity: Minor
Diflunisal and Methyl aminolevulinate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methyl aminolevulinate is used topically with light for photodynamic therapy, and systemic photosensitizing drugs may intensify the skin reaction at the treated site. Systemic exposure to the topical agent is minimal, so clinical significance is probably small.
What this interaction means in plain words
Diflunisal and Methyl aminolevulinate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive phototoxicity at the illuminated skin site.
What to do
Counsel patients to protect treated skin from light after therapy and report severe local reactions. Review other photosensitizing drugs before treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Diflunisal with Methyl aminolevulinate?
MediHelp rates the interaction as minor. Diflunisal and Methyl aminolevulinate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methyl aminolevulinate is used topically with light for photodynamic therapy, and systemic photosensitizing drugs may intensify the skin reaction at the treated site. Systemic exposure to the topical agent is minimal, so clinical significance is probably small.
How serious is the interaction between Diflunisal and Methyl aminolevulinate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to protect treated skin from light after therapy and report severe local reactions. Review other photosensitizing drugs before treatment.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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