Drug interactions
Diflunisal + Mycophenolate
Severity: Moderate
Diflunisal and Mycophenolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diflunisal may raise exposure to mycophenolic acid glucuronide and possibly the active metabolite. NSAIDs also add gastrointestinal irritation and renal risk in transplant patients.
What this interaction means in plain words
Diflunisal and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion and glucuronidation pathways may reduce clearance of mycophenolate metabolites.
What to do
Monitor for mycophenolate adverse effects such as GI upset and myelosuppression, and monitor renal function. Prefer a non-NSAID analgesic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Diflunisal with Mycophenolate?
MediHelp rates the interaction as moderate. Diflunisal and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diflunisal may raise exposure to mycophenolic acid glucuronide and possibly the active metabolite. NSAIDs also add gastrointestinal irritation and renal risk in transplant patients.
How serious is the interaction between Diflunisal and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mycophenolate adverse effects such as GI upset and myelosuppression, and monitor renal function. Prefer a non-NSAID analgesic where possible.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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