Drug interactions
Diflunisal + Nefazodone
Severity: Moderate
Diflunisal and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
An NSAID combined with a serotonergic antidepressant increases the risk of upper gastrointestinal and other bleeding. The risk rises with age, prior ulcers or additional anticoagulant use.
What this interaction means in plain words
Diflunisal and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antidepressant-induced platelet serotonin depletion adds to NSAID platelet inhibition and mucosal injury.
What to do
Monitor for GI bleeding and consider a proton pump inhibitor in at-risk patients. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Diflunisal with Nefazodone?
MediHelp rates the interaction as moderate. Diflunisal and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. An NSAID combined with a serotonergic antidepressant increases the risk of upper gastrointestinal and other bleeding. The risk rises with age, prior ulcers or additional anticoagulant use.
How serious is the interaction between Diflunisal and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding and consider a proton pump inhibitor in at-risk patients. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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