Drug interactions
Diflunisal + Neomycin po
Severity: Minor
Diflunisal and Neomycin po: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal function and have been shown to raise aminoglycoside levels in preterm infants. Oral neomycin is poorly absorbed, so systemic exposure in adults is generally minimal.
What this interaction means in plain words
Diflunisal and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
NSAID-related reduction in renal prostaglandins and glomerular filtration may reduce aminoglycoside clearance.
What to do
No action is usually needed in adults; in neonates or patients with renal impairment or damaged gut mucosa, monitor renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Diflunisal with Neomycin po?
MediHelp rates the interaction as minor. Diflunisal and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can reduce renal function and have been shown to raise aminoglycoside levels in preterm infants. Oral neomycin is poorly absorbed, so systemic exposure in adults is generally minimal.
How serious is the interaction between Diflunisal and Neomycin po?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is usually needed in adults; in neonates or patients with renal impairment or damaged gut mucosa, monitor renal function.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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