Drug interactions
Diflunisal + Sodium citrate / citric acid
Severity: Minor
Diflunisal and Sodium citrate / citric acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Citrate is metabolized to bicarbonate and alkalinizes urine, which increases renal excretion of salicylates. Diflunisal exposure might fall slightly, with limited clinical effect.
What this interaction means in plain words
Diflunisal and Sodium citrate / citric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Urinary alkalinization ionizes salicylate derivatives, reducing tubular reabsorption and increasing excretion.
What to do
No routine adjustment is needed; reassess pain control if citrate alkalinizing therapy is used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Diflunisal with Sodium citrate / citric acid?
MediHelp rates the interaction as minor. Diflunisal and Sodium citrate / citric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Citrate is metabolized to bicarbonate and alkalinizes urine, which increases renal excretion of salicylates. Diflunisal exposure might fall slightly, with limited clinical effect.
How serious is the interaction between Diflunisal and Sodium citrate / citric acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; reassess pain control if citrate alkalinizing therapy is used long term.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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