Drug interactions
Diflunisal + Sulfadiazine
Severity: Minor
Diflunisal and Sulfadiazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs that are highly protein bound may displace sulfonamides from albumin and compete for renal secretion. This could modestly raise free sulfadiazine concentrations, but clinical significance is uncertain.
What this interaction means in plain words
Diflunisal and Sulfadiazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible protein-binding displacement and competition for renal tubular secretion; mechanism not firmly established.
What to do
No routine change is needed; monitor for sulfonamide adverse effects and renal function in patients with kidney impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Diflunisal with Sulfadiazine?
MediHelp rates the interaction as minor. Diflunisal and Sulfadiazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs that are highly protein bound may displace sulfonamides from albumin and compete for renal secretion. This could modestly raise free sulfadiazine concentrations, but clinical significance is uncertain.
How serious is the interaction between Diflunisal and Sulfadiazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor for sulfonamide adverse effects and renal function in patients with kidney impairment.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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