Drug interactions
Diflunisal + Sulfisoxazole
Severity: Minor
Diflunisal and Sulfisoxazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diflunisal may raise sulfisoxazole concentrations through protein-binding displacement or reduced renal elimination. The effect is likely small and of uncertain clinical importance.
What this interaction means in plain words
Diflunisal and Sulfisoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible protein-binding displacement and competition for renal tubular secretion; mechanism not firmly established.
What to do
No routine adjustment is needed; monitor for sulfonamide toxicity and renal function in vulnerable patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Diflunisal with Sulfisoxazole?
MediHelp rates the interaction as minor. Diflunisal and Sulfisoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diflunisal may raise sulfisoxazole concentrations through protein-binding displacement or reduced renal elimination. The effect is likely small and of uncertain clinical importance.
How serious is the interaction between Diflunisal and Sulfisoxazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for sulfonamide toxicity and renal function in vulnerable patients.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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