Drug interactions
Diflunisal + Temocillin
Severity: Minor
Diflunisal and Temocillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diflunisal may reduce renal tubular secretion of penicillins and is highly protein bound, so it may raise temocillin levels. This could increase exposure to the antibiotic, though this is usually of limited clinical significance.
What this interaction means in plain words
Diflunisal and Temocillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion transport and plasma protein binding.
What to do
No dose change is usually needed. Monitor for beta-lactam adverse effects in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Diflunisal with Temocillin?
MediHelp rates the interaction as minor. Diflunisal and Temocillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diflunisal may reduce renal tubular secretion of penicillins and is highly protein bound, so it may raise temocillin levels. This could increase exposure to the antibiotic, though this is usually of limited clinical significance.
How serious is the interaction between Diflunisal and Temocillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for beta-lactam adverse effects in patients with renal impairment.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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