Drug interactions
Diflunisal + Ticarcillin
Severity: Minor
Diflunisal and Ticarcillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticarcillin can impair platelet function at high doses, and diflunisal also inhibits platelets, so bleeding risk may be modestly increased. Diflunisal may also reduce tubular secretion of penicillins, raising ticarcillin exposure.
What this interaction means in plain words
Diflunisal and Ticarcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular anion secretion plus additive effects on platelet function.
What to do
No dose change is usually required. Monitor for bleeding and renal function in high-dose or renally impaired patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Diflunisal with Ticarcillin?
MediHelp rates the interaction as minor. Diflunisal and Ticarcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ticarcillin can impair platelet function at high doses, and diflunisal also inhibits platelets, so bleeding risk may be modestly increased. Diflunisal may also reduce tubular secretion of penicillins, raising ticarcillin exposure.
How serious is the interaction between Diflunisal and Ticarcillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required. Monitor for bleeding and renal function in high-dose or renally impaired patients.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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