Drug interactions
Dihydroergotamine intranasal + Isoproterenol
Severity: Moderate
Dihydroergotamine intranasal and Isoproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal dihydroergotamine is systemically absorbed and causes vasoconstriction, while isoproterenol is a beta agonist that causes tachycardia and vasodilation. The effects are largely opposed but cardiac stimulation with ergot vasospasm may be harmful. Evidence is limited.
What this interaction means in plain words
Dihydroergotamine intranasal and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing vasoactive effects with additive cardiac stress; no established synergistic mechanism.
What to do
Monitor blood pressure, heart rate and ECG, and watch for ischemic symptoms when both are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoproterenol
Frequently asked questions
Can I take Dihydroergotamine intranasal with Isoproterenol?
MediHelp rates the interaction as moderate. Dihydroergotamine intranasal and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intranasal dihydroergotamine is systemically absorbed and causes vasoconstriction, while isoproterenol is a beta agonist that causes tachycardia and vasodilation. The effects are largely opposed but cardiac stimulation with ergot vasospasm may be harmful. Evidence is limited.
How serious is the interaction between Dihydroergotamine intranasal and Isoproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG, and watch for ischemic symptoms when both are used.
What other medicines interact with Isoproterenol?
MediHelp also lists interactions of Isoproterenol with, for example, Adrenaline-articaine, Bisoprolol, Budesonide-formoterol. The full list is on the Isoproterenol page.
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