Drug interactions
Dihydroergotamine intranasal + Nadolol
Severity: Moderate
Dihydroergotamine intranasal and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers may augment ergot-induced vasoconstriction by blocking beta-2 mediated vasodilation. This could cause peripheral ischemia or raised blood pressure.
What this interaction means in plain words
Dihydroergotamine intranasal and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Blockade of beta-2 vasodilation combined with ergot vasoconstrictive effects.
What to do
Monitor for cold, numb or painful extremities and blood pressure. Stop dihydroergotamine if ischemic symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
Frequently asked questions
Can I take Dihydroergotamine intranasal with Nadolol?
MediHelp rates the interaction as moderate. Dihydroergotamine intranasal and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers may augment ergot-induced vasoconstriction by blocking beta-2 mediated vasodilation. This could cause peripheral ischemia or raised blood pressure.
How serious is the interaction between Dihydroergotamine intranasal and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cold, numb or painful extremities and blood pressure. Stop dihydroergotamine if ischemic symptoms appear.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Amifostine. The full list is on the Nadolol page.
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