Drug interactions
Dihydroergotamine intranasal + Secobarbital
Severity: Moderate
Dihydroergotamine intranasal and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may lower systemic dihydroergotamine exposure from the nasal route and reduce migraine relief.
What this interaction means in plain words
Dihydroergotamine intranasal and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by barbiturates increases dihydroergotamine metabolism.
What to do
Monitor for diminished headache response and consider alternative sedatives or antimigraine therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Dihydroergotamine intranasal with Secobarbital?
MediHelp rates the interaction as moderate. Dihydroergotamine intranasal and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital may lower systemic dihydroergotamine exposure from the nasal route and reduce migraine relief.
How serious is the interaction between Dihydroergotamine intranasal and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diminished headache response and consider alternative sedatives or antimigraine therapy.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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