Drug interactions
Dihydroergotamine intranasal + Sertraline
Severity: Moderate
Dihydroergotamine intranasal and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have serotonergic activity, and the combination has been associated with a theoretical risk of serotonin syndrome. Intranasal dihydroergotamine is systemically absorbed, so the concern applies.
What this interaction means in plain words
Dihydroergotamine intranasal and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects at serotonin receptors and reuptake.
What to do
Counsel patients on symptoms of serotonin syndrome and monitor after starting or increasing doses. Stop dihydroergotamine if signs of serotonin toxicity appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Dihydroergotamine intranasal with Sertraline?
MediHelp rates the interaction as moderate. Dihydroergotamine intranasal and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have serotonergic activity, and the combination has been associated with a theoretical risk of serotonin syndrome. Intranasal dihydroergotamine is systemically absorbed, so the concern applies.
How serious is the interaction between Dihydroergotamine intranasal and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients on symptoms of serotonin syndrome and monitor after starting or increasing doses. Stop dihydroergotamine if signs of serotonin toxicity appear.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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