Drug interactions
Dihydroergotamine intranasal + Zolmitriptan
Severity: Contraindicated
Dihydroergotamine intranasal and Zolmitriptan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal dihydroergotamine is absorbed systemically and retains its vasoconstrictor potency, so adding zolmitriptan raises the risk of prolonged vasospasm. Cardiac, cerebral or peripheral ischemia may result.
What this interaction means in plain words
Dihydroergotamine intranasal and Zolmitriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive vasoconstriction via 5-HT1B/1D receptor agonism and ergot vascular receptor effects.
What to do
Do not use together; wait at least 24 hours between the drugs. Select one acute migraine therapy per attack.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
- Frovatriptan + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine intranasal with Zolmitriptan?
MediHelp rates the interaction as contraindicated. Dihydroergotamine intranasal and Zolmitriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Intranasal dihydroergotamine is absorbed systemically and retains its vasoconstrictor potency, so adding zolmitriptan raises the risk of prolonged vasospasm. Cardiac, cerebral or peripheral ischemia may result.
How serious is the interaction between Dihydroergotamine intranasal and Zolmitriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; wait at least 24 hours between the drugs. Select one acute migraine therapy per attack.
What other medicines interact with Zolmitriptan?
MediHelp also lists interactions of Zolmitriptan with, for example, Almotriptan, Dihydroergotamine, Eletriptan. The full list is on the Zolmitriptan page.
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