Drug interactions
Ergoloid mesylates + Zolmitriptan
Severity: Contraindicated
Ergoloid mesylates and Zolmitriptan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents act on serotonergic and vascular receptors, so concurrent use may add to vasoconstriction. Ergoloid has weaker vasoconstrictor activity than other ergots, but triptan labeling still warns against ergot-type drugs.
What this interaction means in plain words
Ergoloid mesylates and Zolmitriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive vasoconstriction through serotonin receptor agonism and ergot-derived receptor effects.
What to do
Avoid combined use and separate by at least 24 hours. Reassess whether ergoloid is needed in patients treated for migraine.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
- Frovatriptan + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Ergoloid mesylates with Zolmitriptan?
MediHelp rates the interaction as contraindicated. Ergoloid mesylates and Zolmitriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents act on serotonergic and vascular receptors, so concurrent use may add to vasoconstriction. Ergoloid has weaker vasoconstrictor activity than other ergots, but triptan labeling still warns against ergot-type drugs.
How serious is the interaction between Ergoloid mesylates and Zolmitriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use and separate by at least 24 hours. Reassess whether ergoloid is needed in patients treated for migraine.
What other medicines interact with Zolmitriptan?
MediHelp also lists interactions of Zolmitriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Zolmitriptan page.
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