Drug interactions
Dihydroergotamine + Zolmitriptan
Severity: Contraindicated
Dihydroergotamine and Zolmitriptan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zolmitriptan and dihydroergotamine both cause vasoconstriction, and together they may prolong vasospastic reactions. Serious cardiovascular and cerebrovascular ischemic events are the concern.
What this interaction means in plain words
Dihydroergotamine and Zolmitriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dihydroergotamine belongs to Central Nervous System; Zolmitriptan belongs to Central Nervous System.
Why it happens
Additive vasoconstriction via 5-HT1B/1D receptor agonism and ergot vascular receptor effects.
What to do
Avoid combining them and separate doses by at least 24 hours. Pick one agent per migraine attack.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
- Frovatriptan + Zolmitriptan Contraindicated
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Zolmitriptan?
MediHelp rates the interaction as contraindicated. Dihydroergotamine and Zolmitriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Zolmitriptan and dihydroergotamine both cause vasoconstriction, and together they may prolong vasospastic reactions. Serious cardiovascular and cerebrovascular ischemic events are the concern.
How serious is the interaction between Dihydroergotamine and Zolmitriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them and separate doses by at least 24 hours. Pick one agent per migraine attack.
What other medicines interact with Zolmitriptan?
MediHelp also lists interactions of Zolmitriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Eletriptan. The full list is on the Zolmitriptan page.
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