Drug interactions
Diltiazem + Dutasteride-tamsulosin
Severity: Moderate
Diltiazem and Dutasteride-tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem is a moderate CYP3A4 inhibitor and raises tamsulosin and dutasteride exposure. Diltiazem also lowers blood pressure, so the combination can increase dizziness and orthostatic hypotension.
What this interaction means in plain words
Diltiazem and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
Diltiazem inhibits CYP3A4, reducing metabolism of tamsulosin and dutasteride, with additive hypotensive effects.
What to do
Monitor blood pressure and orthostatic symptoms, particularly at initiation. Reduce the tamsulosin dose or choose an alternative if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Dutasteride-tamsulosin?
MediHelp rates the interaction as moderate. Diltiazem and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem is a moderate CYP3A4 inhibitor and raises tamsulosin and dutasteride exposure. Diltiazem also lowers blood pressure, so the combination can increase dizziness and orthostatic hypotension.
How serious is the interaction between Diltiazem and Dutasteride-tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, particularly at initiation. Reduce the tamsulosin dose or choose an alternative if hypotension occurs.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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