Drug interactions
Diltiazem + Duvelisib
Severity: Moderate
Diltiazem and Duvelisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and may raise diltiazem concentrations, increasing hypotension and bradycardia risk. Duvelisib is itself metabolized by CYP3A4, so diltiazem may increase its exposure too.
What this interaction means in plain words
Diltiazem and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Duvelisib belongs to Oncology.
Why it happens
Duvelisib inhibits CYP3A4, reducing diltiazem metabolism; diltiazem in turn inhibits CYP3A4 metabolism of duvelisib.
What to do
Consider reducing the diltiazem dose and monitor blood pressure, heart rate and ECG. Reduce duvelisib dose per labeling when given with a moderate CYP3A4 inhibitor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Diltiazem with Duvelisib?
MediHelp rates the interaction as moderate. Diltiazem and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and may raise diltiazem concentrations, increasing hypotension and bradycardia risk. Duvelisib is itself metabolized by CYP3A4, so diltiazem may increase its exposure too.
How serious is the interaction between Diltiazem and Duvelisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the diltiazem dose and monitor blood pressure, heart rate and ECG. Reduce duvelisib dose per labeling when given with a moderate CYP3A4 inhibitor.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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