Drug interactions
Diltiazem + Elacestrant
Severity: Moderate
Diltiazem and Elacestrant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may increase elacestrant plasma concentrations. This could increase elacestrant adverse effects such as nausea, musculoskeletal pain and dyslipidemia.
What this interaction means in plain words
Diltiazem and Elacestrant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Elacestrant belongs to Oncology.
Why it happens
Diltiazem is a moderate CYP3A4 inhibitor and reduces the metabolic clearance of elacestrant.
What to do
Avoid combining where an alternative to diltiazem is feasible. If used together, monitor for elacestrant adverse effects and consider whether labeling-based dose changes apply.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Elacestrant
Frequently asked questions
Can I take Diltiazem with Elacestrant?
MediHelp rates the interaction as moderate. Diltiazem and Elacestrant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem may increase elacestrant plasma concentrations. This could increase elacestrant adverse effects such as nausea, musculoskeletal pain and dyslipidemia.
How serious is the interaction between Diltiazem and Elacestrant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where an alternative to diltiazem is feasible. If used together, monitor for elacestrant adverse effects and consider whether labeling-based dose changes apply.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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