Drug interactions
Apalutamide + Elacestrant
Severity: Major
Apalutamide and Elacestrant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide markedly reduces exposure to CYP3A4 substrates such as elacestrant. This may compromise the efficacy of breast cancer therapy.
What this interaction means in plain words
Apalutamide and Elacestrant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Elacestrant belongs to Oncology.
Why it happens
Apalutamide induces CYP3A4, accelerating elacestrant metabolism.
What to do
Avoid coadministration; elacestrant labeling advises against strong CYP3A4 inducers. Use an alternative agent if possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Elacestrant
Frequently asked questions
Can I take Apalutamide with Elacestrant?
MediHelp rates the interaction as major. Apalutamide and Elacestrant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide markedly reduces exposure to CYP3A4 substrates such as elacestrant. This may compromise the efficacy of breast cancer therapy.
How serious is the interaction between Apalutamide and Elacestrant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration; elacestrant labeling advises against strong CYP3A4 inducers. Use an alternative agent if possible.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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