Drug interactions
Diltiazem + Isavuconazonium
Severity: Moderate
Diltiazem and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole, released from isavuconazonium, is a CYP3A4 substrate, and diltiazem may raise its concentrations. The effect from a moderate inhibitor is expected to be modest. Isavuconazole may also inhibit diltiazem metabolism.
What this interaction means in plain words
Diltiazem and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Isavuconazonium belongs to Anti Fungals.
Why it happens
Diltiazem inhibits CYP3A4, reducing isavuconazole clearance.
What to do
Monitor for isavuconazole adverse effects such as hepatic enzyme elevation and QT shortening, and watch diltiazem effects (heart rate, blood pressure).
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Diltiazem with Isavuconazonium?
MediHelp rates the interaction as moderate. Diltiazem and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole, released from isavuconazonium, is a CYP3A4 substrate, and diltiazem may raise its concentrations. The effect from a moderate inhibitor is expected to be modest. Isavuconazole may also inhibit diltiazem metabolism.
How serious is the interaction between Diltiazem and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for isavuconazole adverse effects such as hepatic enzyme elevation and QT shortening, and watch diltiazem effects (heart rate, blood pressure).
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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