Drug interactions
Diltiazem + Lemborexant
Severity: Moderate
Diltiazem and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem increases lemborexant exposure, which may cause greater next-day somnolence and impaired psychomotor performance.
What this interaction means in plain words
Diltiazem and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Lemborexant belongs to Central Nervous System.
Why it happens
Diltiazem inhibits CYP3A4, the main metabolic pathway of lemborexant.
What to do
Limit lemborexant to 5 mg once nightly when used with moderate CYP3A inhibitors per labeling. Counsel on next-day drowsiness and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Diltiazem with Lemborexant?
MediHelp rates the interaction as moderate. Diltiazem and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem increases lemborexant exposure, which may cause greater next-day somnolence and impaired psychomotor performance.
How serious is the interaction between Diltiazem and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit lemborexant to 5 mg once nightly when used with moderate CYP3A inhibitors per labeling. Counsel on next-day drowsiness and driving.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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