Drug interactions
Diltiazem + Memantine-donepezil
Severity: Moderate
Diltiazem and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem inhibits CYP3A4 and may modestly raise donepezil exposure. Both drugs can slow heart rate, so bradycardia or AV block may be more likely.
What this interaction means in plain words
Diltiazem and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Memantine-donepezil belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition reduces donepezil metabolism, with additive negative chronotropic effects.
What to do
Monitor heart rate and watch for syncope, dizziness, and cholinergic adverse effects. Reduce the donepezil dose if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Memantine-donepezil?
MediHelp rates the interaction as moderate. Diltiazem and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem inhibits CYP3A4 and may modestly raise donepezil exposure. Both drugs can slow heart rate, so bradycardia or AV block may be more likely.
How serious is the interaction between Diltiazem and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and watch for syncope, dizziness, and cholinergic adverse effects. Reduce the donepezil dose if these occur.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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