Drug interactions
Diltiazem + Mifepristone
Severity: Major
Diltiazem and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone is a CYP3A4 inhibitor and can increase diltiazem levels, raising the risk of bradycardia and hypotension. Diltiazem may in turn increase mifepristone exposure.
What this interaction means in plain words
Diltiazem and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diltiazem belongs to Cardiovascular; Mifepristone belongs to Endocrine.
Why it happens
Mutual CYP3A4 inhibition reduces clearance of both drugs.
What to do
Monitor heart rate, blood pressure and ECG, and reduce the diltiazem dose if bradycardia or hypotension occurs. Use the lowest effective mifepristone dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Diltiazem with Mifepristone?
MediHelp rates the interaction as major. Diltiazem and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone is a CYP3A4 inhibitor and can increase diltiazem levels, raising the risk of bradycardia and hypotension. Diltiazem may in turn increase mifepristone exposure.
How serious is the interaction between Diltiazem and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, and reduce the diltiazem dose if bradycardia or hypotension occurs. Use the lowest effective mifepristone dose.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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