Drug interactions
Diltiazem + Nadolol
Severity: Major
Diltiazem and Nadolol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs slow AV conduction and heart rate and reduce contractility. Combined use can cause severe bradycardia, AV block, hypotension and heart failure decompensation.
What this interaction means in plain words
Diltiazem and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diltiazem belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
Why it happens
Additive negative chronotropic, dromotropic and inotropic effects of calcium channel blockade and beta blockade.
What to do
If used together, monitor ECG, heart rate and blood pressure closely, especially at initiation. Avoid in patients with conduction disease or reduced ventricular function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Nadolol
Frequently asked questions
Can I take Diltiazem with Nadolol?
MediHelp rates the interaction as major. Diltiazem and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs slow AV conduction and heart rate and reduce contractility. Combined use can cause severe bradycardia, AV block, hypotension and heart failure decompensation.
How serious is the interaction between Diltiazem and Nadolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If used together, monitor ECG, heart rate and blood pressure closely, especially at initiation. Avoid in patients with conduction disease or reduced ventricular function.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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