Drug interactions
Diltiazem + Naloxegol
Severity: Moderate
Diltiazem and Naloxegol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem raises naloxegol concentrations, increasing the risk of opioid-withdrawal-like symptoms and gastrointestinal effects such as abdominal pain and diarrhea.
What this interaction means in plain words
Diltiazem and Naloxegol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Naloxegol belongs to Gastrointestinal Tract.
Why it happens
Diltiazem inhibits CYP3A4 and P-gp, decreasing naloxegol clearance.
What to do
Reduce naloxegol to 12.5 mg once daily. Monitor for abdominal pain, diarrhea and withdrawal symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Itraconazole + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Bupropion-naltrexone + Naloxegol Major
Frequently asked questions
Can I take Diltiazem with Naloxegol?
MediHelp rates the interaction as moderate. Diltiazem and Naloxegol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem raises naloxegol concentrations, increasing the risk of opioid-withdrawal-like symptoms and gastrointestinal effects such as abdominal pain and diarrhea.
How serious is the interaction between Diltiazem and Naloxegol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce naloxegol to 12.5 mg once daily. Monitor for abdominal pain, diarrhea and withdrawal symptoms.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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