Drug interactions
Itraconazole + Naloxegol
Severity: Contraindicated
Itraconazole and Naloxegol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole markedly raises naloxegol plasma concentrations. Higher exposure can cause opioid withdrawal symptoms and gastrointestinal adverse effects such as abdominal pain and diarrhea, especially in patients taking opioids chronically.
What this interaction means in plain words
Itraconazole and Naloxegol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Itraconazole belongs to Anti Fungals; Naloxegol belongs to Gastrointestinal Tract.
Why it happens
Strong CYP3A4 inhibition (and P-glycoprotein inhibition) by itraconazole reduces first-pass and systemic clearance of naloxegol.
What to do
Do not co-administer; use an alternative laxative approach or a non-azole antifungal while treating with itraconazole. Naloxegol labeling contraindicates strong CYP3A4 inhibitors.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Itraconazole and Naloxegol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Bupropion-naltrexone + Naloxegol Major
- Carbamazepine + Naloxegol Major
Frequently asked questions
Can I take Itraconazole with Naloxegol?
MediHelp rates the interaction as contraindicated. Itraconazole and Naloxegol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole markedly raises naloxegol plasma concentrations. Higher exposure can cause opioid withdrawal symptoms and gastrointestinal adverse effects such as abdominal pain and diarrhea, especially in patients taking opioids chronically.
How serious is the interaction between Itraconazole and Naloxegol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use an alternative laxative approach or a non-azole antifungal while treating with itraconazole. Naloxegol labeling contraindicates strong CYP3A4 inhibitors.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
