Drug interactions
Bupropion-naltrexone + Naloxegol
Severity: Major
Bupropion-naltrexone and Naloxegol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naltrexone and naloxegol both antagonize opioid receptors, so combining them can add to withdrawal risk in opioid-treated patients. Naltrexone also blocks the opioid analgesia that creates the need for naloxegol.
What this interaction means in plain words
Bupropion-naltrexone and Naloxegol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bupropion-naltrexone belongs to Miscellaneous; Naloxegol belongs to Gastrointestinal Tract.
Why it happens
Additive opioid receptor antagonism.
What to do
Avoid the combination. Use a different constipation regimen or reconsider bupropion-naltrexone, and watch for withdrawal symptoms if used.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bupropion-naltrexone and Naloxegol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Itraconazole + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Carbamazepine + Naloxegol Major
Frequently asked questions
Can I take Bupropion-naltrexone with Naloxegol?
MediHelp rates the interaction as major. Bupropion-naltrexone and Naloxegol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Naltrexone and naloxegol both antagonize opioid receptors, so combining them can add to withdrawal risk in opioid-treated patients. Naltrexone also blocks the opioid analgesia that creates the need for naloxegol.
How serious is the interaction between Bupropion-naltrexone and Naloxegol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Use a different constipation regimen or reconsider bupropion-naltrexone, and watch for withdrawal symptoms if used.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
