Drug interactions
Diltiazem + Nimodipine
Severity: Moderate
Diltiazem and Nimodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem inhibits CYP3A4 and can raise nimodipine concentrations. This may cause hypotension, bradycardia and other dose-related effects, and both drugs lower blood pressure.
What this interaction means in plain words
Diltiazem and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Nimodipine belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition by diltiazem reduces nimodipine clearance, with additive calcium channel blockade.
What to do
Monitor blood pressure and heart rate. Reduce the nimodipine dose if hypotension develops, or avoid concurrent use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Nimodipine?
MediHelp rates the interaction as moderate. Diltiazem and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem inhibits CYP3A4 and can raise nimodipine concentrations. This may cause hypotension, bradycardia and other dose-related effects, and both drugs lower blood pressure.
How serious is the interaction between Diltiazem and Nimodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate. Reduce the nimodipine dose if hypotension develops, or avoid concurrent use.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
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