Drug interactions
Diltiazem + Oliceridine
Severity: Moderate
Diltiazem and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may increase oliceridine concentrations through CYP3A4 inhibition, increasing the risk of sedation and respiratory depression. Stopping diltiazem later could reduce opioid effect.
What this interaction means in plain words
Diltiazem and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Oliceridine belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4 metabolism of oliceridine by diltiazem.
What to do
Monitor for respiratory depression and sedation and extend dosing intervals or lower doses as needed. Re-titrate if diltiazem is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Diltiazem with Oliceridine?
MediHelp rates the interaction as moderate. Diltiazem and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem may increase oliceridine concentrations through CYP3A4 inhibition, increasing the risk of sedation and respiratory depression. Stopping diltiazem later could reduce opioid effect.
How serious is the interaction between Diltiazem and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for respiratory depression and sedation and extend dosing intervals or lower doses as needed. Re-titrate if diltiazem is discontinued.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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