Drug interactions
Diltiazem + Riociguat
Severity: Moderate
Diltiazem and Riociguat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Riociguat lowers blood pressure through soluble guanylate cyclase stimulation, and combining it with diltiazem may cause additive hypotension, dizziness or syncope.
What this interaction means in plain words
Diltiazem and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Riociguat belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic vasodilatory and hypotensive effects.
What to do
Monitor blood pressure and symptoms of hypotension, and consider a lower riociguat starting dose with careful titration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Diltiazem with Riociguat?
MediHelp rates the interaction as moderate. Diltiazem and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Riociguat lowers blood pressure through soluble guanylate cyclase stimulation, and combining it with diltiazem may cause additive hypotension, dizziness or syncope.
How serious is the interaction between Diltiazem and Riociguat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension, and consider a lower riociguat starting dose with careful titration.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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