Drug interactions
Diltiazem + Sarecycline
Severity: Minor
Diltiazem and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline is a weak CYP3A4 inducer and P-gp effects are of uncertain clinical relevance, so any change in diltiazem exposure is likely small.
What this interaction means in plain words
Diltiazem and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diltiazem belongs to Cardiovascular; Sarecycline belongs to Anti Bacterial.
Why it happens
Possible weak P-glycoprotein interaction; the mechanism is not firmly established.
What to do
No routine adjustment is needed; monitor blood pressure and heart rate if symptoms change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Diltiazem with Sarecycline?
MediHelp rates the interaction as minor. Diltiazem and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline is a weak CYP3A4 inducer and P-gp effects are of uncertain clinical relevance, so any change in diltiazem exposure is likely small.
How serious is the interaction between Diltiazem and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor blood pressure and heart rate if symptoms change.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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