Drug interactions
Calcium carbonate + Sarecycline
Severity: Moderate
Calcium carbonate and Sarecycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium may bind sarecycline in the gut and reduce its absorption. Lower exposure could reduce efficacy in acne treatment.
What this interaction means in plain words
Calcium carbonate and Sarecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Sarecycline belongs to Anti Bacterial.
Why it happens
Chelation of the tetracycline-class drug by calcium cations reduces gastrointestinal absorption.
What to do
Separate sarecycline and calcium carbonate by at least 2 to 3 hours. Counsel the patient on dosing times.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium + Sarecycline Moderate
- Carbonyl iron + Sarecycline Moderate
Frequently asked questions
Can I take Calcium carbonate with Sarecycline?
MediHelp rates the interaction as moderate. Calcium carbonate and Sarecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium may bind sarecycline in the gut and reduce its absorption. Lower exposure could reduce efficacy in acne treatment.
How serious is the interaction between Calcium carbonate and Sarecycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate sarecycline and calcium carbonate by at least 2 to 3 hours. Counsel the patient on dosing times.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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