Drug interactions
Calcium + Sarecycline
Severity: Moderate
Calcium and Sarecycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral calcium can bind sarecycline in the gut and may reduce its absorption, although sarecycline is somewhat less affected than older tetracyclines. This could reduce acne treatment efficacy.
What this interaction means in plain words
Calcium and Sarecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium belongs to Gastrointestinal Tract; Sarecycline belongs to Anti Bacterial.
Why it happens
Chelation of the tetracycline by calcium cations in the gastrointestinal tract.
What to do
Separate sarecycline from calcium supplements and antacids by at least 2 to 3 hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Carbonyl iron + Sarecycline Moderate
Frequently asked questions
Can I take Calcium with Sarecycline?
MediHelp rates the interaction as moderate. Calcium and Sarecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral calcium can bind sarecycline in the gut and may reduce its absorption, although sarecycline is somewhat less affected than older tetracyclines. This could reduce acne treatment efficacy.
How serious is the interaction between Calcium and Sarecycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate sarecycline from calcium supplements and antacids by at least 2 to 3 hours.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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